ZFIN is now using GRCz12tu for Genomic Data
Gene
adamts16
- ID
- ZDB-GENE-130530-760
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 16
- Symbol
- adamts16 Nomenclature History
- Previous Names
-
- zmp:0000000757 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; muscle; optic cup; and pleuroperitoneal region. Used to study coloboma.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | AB + MO2-adamts16 | standard conditions | Cao et al., 2018 |
| coloboma | AB + MO1-adamts16 | standard conditions | Cao et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR010909 | PLAC |
| Domain | IPR041645 | ADAMTS, cysteine-rich domain 2 |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 repeat superfamily | Thrombospondin type-1 (TSP1) repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FFX0 | InterPro | 1224 | |||||||||||
| UniProtKB:A0AC58HIJ1 | InterPro | 1062 | |||||||||||
| UniProtKB:A0ACD6B5W4 | InterPro | 1224 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts16-201
(1)
|
Ensembl | 3,973 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-adamts16 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
2 |
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance