ZFIN is now using GRCz12tu for Genomic Data

Gene

ins

ID

ZDB-GENE-980526-110

Name

preproinsulin

Symbol

ins Nomenclature History

Previous Names

insa (1)
zgc:109842

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable hormone activity. Acts upstream of or within several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

351 figures from 213 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109842 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ins Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
maturity-onset diabetes of the young type 10	Alliance	Maturity-onset diabetes of the young, type 10	613370
type 1 diabetes mellitus 2	Alliance	Diabetes mellitus, insulin-dependent, 2	125852
		Diabetes mellitus, permanent neonatal 4	618858
		Hyperproinsulinemia	616214

Associated With ins Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022353	Insulin, conserved site
Domain	IPR016179	Insulin-like
Family	IPR004825	Insulin
Homologous_superfamily	IPR036438	Insulin-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Insulin	Insulin, conserved site	Insulin-like	Insulin-like superfamily
UniProtKB:B2GSI0	InterPro	108
UniProtKB:O73727	InterPro	108

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ins-201 (1) Ensembl	Ensembl		485 nt	Select Tool ZFIN BLAST
mRNA	ins-202 (1) Ensembl	Ensembl		331 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Host Organism	Assay	Source	Citations
Ab2-ins	polyclonal	ins	Guinea pig	IHC	Biomeda Corporation	7
Ab6-ins	polyclonal	ins	Guinea pig	IHC	Abcam plc	3
Ab1-ins	polyclonal	ins	Guinea pig	IHC	Dako North America, Inc.	37
Ab3-ins	polyclonal	ins	Guinea pig	IHC	Millipore	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations