ZFIN is now using GRCz12tu for Genomic Data
Gene
isl1a
- ID
- ZDB-GENE-980526-112
- Name
- ISL LIM homeobox 1a
- Symbol
- isl1a Nomenclature History
- Previous Names
-
- Isl-1 (1)
- isl1
- islet-1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in sinoatrial node cell development. Acts upstream of or within several processes, including endocrine pancreas development; exocrine pancreas development; and neuron differentiation. Located in nucleus. Is expressed in several structures, including heart; mesoderm; nervous system; pancreatic system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 310 figures from 224 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73031 (12 images)
- eu243 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 33 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001781 | Zinc finger, LIM-type |
| Domain | IPR047244 | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 |
| Family | IPR047169 | Insulin gene enhancer protein ISL-1/2-like |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Insulin gene enhancer protein ISL-1/2-like | Insulin gene enhancer protein ISL-1/2-like, LIM domain1 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BCL0 | InterPro | 348 | ||||||
| UniProtKB:A0A8M9PJN3 | InterPro | 257 | ||||||
| UniProtKB:P53405 | InterPro | 349 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-isl | monoclonal | IgG1 | Mouse |
|
Developmental Studies Hybridoma Bank
|
29 | |
| Ab5-isl1 | monoclonal | IgG1 | Mouse |
|
Developmental Studies Hybridoma Bank
|
2 | |
| Ab1-isl1 | polyclonal | IgG | Rabbit |
|
2 | ||
| Ab2-isl | monoclonal | IgG2b | Mouse |
|
Developmental Studies Hybridoma Bank
|
147 |
Plasmids
No data available
- Genome Browsers