Gene
fgfr4
- ID
- ZDB-GENE-980526-488
- Name
- fibroblast growth factor receptor 4
- Symbol
- fgfr4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in endoplasmic reticulum and endosome. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; head; and head mesenchyme. Human ortholog(s) of this gene implicated in carcinoma (multiple); liver cirrhosis; prostate cancer; and stomach cancer. Orthologous to human FGFR4 (fibroblast growth factor receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Cancer progression/metastasis} |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013151 | Immunoglobulin-like beta-sandwich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90413 | InterPro | 922 | ||||||||||||||
| UniProtKB:A0AB32TG28 | InterPro | 923 |
Interactions and Pathways
Plasmids
No data available