lft1

ID

ZDB-GENE-990630-10

Name

lefty1

Symbol

lft1 Nomenclature History

Previous Names

antivin
atv
cb73 (1)
ik:tdsubc_2b12
xx:tdsubc_2b12

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity. Acts upstream of or within determination of left/right symmetry; dorsal/ventral pattern formation; and embryonic heart tube development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; brain; germ ring; mesoderm; and tail bud. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including LEFTY2 (left-right determination factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

155 figures from 107 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb73 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lft1 Human Ortholog

No data available

Associated With lft1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR003942	Left- Right determination factor
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine