ZFIN is now using GRCz12tu for Genomic Data
Gene
krt5
- ID
- ZDB-GENE-991110-23
- Name
- keratin 5
- Symbol
- krt5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be a structural constituent of skin epidermis. Acts upstream of or within fin regeneration. Predicted to be active in keratin filament. Is expressed in several structures, including embryonic structure; epidermal cell; head; integument; and periderm. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; epidermolysis bullosa simplex (multiple); hypotrichosis (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT8 (keratin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77647 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dowling-Degos disease | Alliance | Dowling-Degos disease 1 | 179850 |
| epidermolysis bullosa simplex 2F with mottled pigmentation | Alliance | Epidermolysis bullosa simplex 2F, with mottled pigmentation | 131960 |
| Epidermolysis bullosa simplex 2A, generalized severe | 619555 | ||
| Epidermolysis bullosa simplex 2B, generalized intermediate | 619588 | ||
| Epidermolysis bullosa simplex 2C, localized | 619594 | ||
| Epidermolysis bullosa simplex 2D, generalized, intermediate or severe, autosomal recessive | 619599 | ||
| Epidermolysis bullosa simplex 2E, with migratory circinate erythema | 609352 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament protein, conserved site | Intermediate filament, rod domain | Keratin, type II | Keratin type II head |
|---|---|---|---|---|---|---|
| UniProtKB:Q6P3K5 | InterPro | 553 | ||||
| UniProtKB:A0A8M6YXS6 | InterPro | 554 | ||||
| UniProtKB:F1QV31 | InterPro | 566 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-krt5 | polyclonal | IgG | Rabbit |
|
Thermo Scientific Pierce Protein Research Products
|
2 |
Plasmids
- Genome Browsers