ZFIN Image: Zhang et al., 2023, FIGURE 2

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Figure Caption

FIGURE 2

Functional study of p.H87Mfs*17 mutation in nebulin-related-anchoring protein (NRAP). (A) Total cell protein expressions of wild-type (WT) vs. the mutated NRAP determined by Western blotting. p.H87Mfs*17 mutation led to decreased expression of NRAP. (B) Quantitative analysis of total cell protein expressions of WT vs. mutated NRAP. All values are means ± SD; n = 6 in each group. ***P < 0.001 vs. control. (C,D) Images of juvenile fish with pericardial edema. Two cases were the wild-type (WT) zebrafish (C) and two cases carried a homozygous mutation of the NRAP allele (D). (E) HE-stained heart tissue of normal zebrafish. (F) HE-stained heart tissue of zebrafish with pericardial edema.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cardiovasc Med