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Figure 5 Comparative transcriptome and proteome analysis of control and rpgrip1l-/- fish. (A, B) Volcano-plots showing differentially regulated genes in the transcriptomes of the brain (A) and dorsal trunk (B) comparing 5 controls (2 wt, 3 rpgrip1l-/+) and 7 rpgrip1l-/- (6 tail-up and 1 straight) fish at 5 wpf (0.9 cm body length). Each dot corresponds to one gene. A gene was considered deregulated if its associated P-adj. value was inferior to 0.05. Red and blue dots represent up-regulated (Log2FC >0.75), and down-regulated (Log2FC 0.75) or depleted (Log2FC
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