ZFIN Image: Cero et al., 2024, Fig. 5

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Figure Caption

Fig. 5 Comparative genomics analysis and candidate gene evaluation in human patient samples identifies potential contributors to MPNST progression.

A Comparison of gene expression profiles for malignant versus benign samples in humans (MPNST and ANNUBP versus neurofibroma) and zebrafish (cancer cells versus potential precancerous cells; cancer microenvironment (ME) versus precancerous ME). Dots represent log₂ fold changes per gene for human (black dots) and zebrafish (purple dots) comparisons and connecting lines (purple) depict the relative shift in log₂ fold change value. B Expression of candidate genes POSTN and CTHRC1 in human MPNST specimens detected by Western blotting and immunohistochemistry. ANNUBP, atypical neurofibromatosis neoplasm of unidentified biologic potential; TMA, tissue microarray.

Acknowledgments

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