ZFIN Image: Sertori et al., 2025, Figure 6

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Figure 6

scRNA-Seq analysis of WT and Chtf18 mut HSPC.(A) Uniform Manifold Approximation Projection (UMAP) plots showing eight distinct HSPC clusters and their relative frequencies in Lineage- HSPC from Chtf18 wildtype and mut mice. (B) Gene Set Enrichment analysis (EnrichGo) of the highly variable expressed genes between Chtf18 wildtype and mut HSC/MPP cluster. (C) Bubble plot representation showing expression of DNA clamp loader proteins and top upregulated genes in the Chtf18 mut HSPCs. (D) Percentage of cells in G1, G2/M and S phase in Chtf18 WT and mut HSPCs. Reference cell type abbreviations: LT-34F, CD34+ Long-term reconstituting stem cell; LT-HSC, CD34- Long-term reconstituting stem cell; MEP, Megakaryocyte-Erythroid Progenitor; CMP, Common Myeloid Progenitor; GMP, Granulocyte-Monocyte Progenitor; MLP, Multilineage Progenitor; HSC/MPP, Hematopoietic Stem Cell and Multi-Potent Progenitor; CLP, Common Lymphoid Progenitor; MDP, Monocyte-Dendritic cell Progenitor; CDP, Common Dendritic cell Progenitor.

Acknowledgments

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