Fig. 6

Fig. 6 Transcriptome analysis of WT and znf706−/− oocytes. A: Bar graph showing the correlations between two biological replicates of WT and znf706−/− oocytes at stages I and II. B: Volcano plots illustrating gene expression changes between WT and znf706−/− oocytes at stages I and II. Red, upregulated genes; Blue, downregulated genes. C: Venn diagram illustrating the overlap between potential Znf706 target genes identified with either promoter (±2 kb of transcription start site) or distal peaks (around ±250 kb of distal peaks) by CUT&Tag and downregulated genes in znf706−/− oocytes by RNA-seq. D: Bar plots showing GO analysis of downregulated genes in znf706−/− oocytes at stages I (left) and II (right). E and F: Bar plots showing the expression levels of germ plasm genes (E) and mitochondrial genes (F) of WT (blue) and znf706−/− (orange) oocytes at stages I and II by RNA-seq. G: UCSC Genome Browser snapshots showing Znf706 and IgG peaks at promoter regions of ppm1h, raf1a, txnipa, and atp1a1a.1. Pink shadows indicated promoter regions. WT, wild-type; st., stage; C&T, CUT&Tag.