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Fig. 3 The c.333del variant affects sugar processing as well as several important intracellular pathways. (A) Results of liquid chromatography–mass spectrometry on serum from individual V-8 indicate a mild reduction of galactose and sialic acid residues. Altered peaks are enlarged for clarity or indicated by a red arrow. Heatmaps of deregulated pathways indicate that loss of SEC24C may influence the (B) “proteasome,” (C) “autophagy,” and (D) “N-glycan biosynthesis” pathways (n = 3/group).
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