FIGURE

Fig. 4

ID

ZDB-FIG-081201-4

Publication

Esterberg et al., 2008 - Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

BMP activity establishes proliferation in axial mesoderm. (A-D″) Longitudinal sections through the tailbud of 14-somite embryos exposed to PSMAD1/5/8 (red) and BrdU (green) antibodies reveal that axial cells undergoing proliferation are responding to BMP activity. Cell proliferation is increased in axial tissue of Fstl1/2 morphants (B-B″), and reduced in tBR embryos heat-shocked at 80% epiboly (C-C″) and Bmp4 morphants (D-D″). Arrowheads indicate the CNH. Anterior is towards the left in all views. Brackets and arrows indicate the expanse and absence of proliferation in chordamesoderm, respectively.

Expression Data

Antibody:	Ab3-smad
Fish:	WT WT + MO3-bmp4 w30Tg WT + MO2-fstl1a + MO4-fstl1b
Condition:	heat shock
Knockdown Reagents:	MO2-fstl1a MO3-bmp4 MO4-fstl1b
Anatomical Terms:	chordo neural hinge notochord
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-bmp4 w30Tg
Condition:	heat shock
Knockdown Reagent:	MO3-bmp4
Observed In:	cell population proliferation notochord development
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development