FIGURE

Figure 3

ID

ZDB-FIG-210310-115

Publication

Harding et al., 2021 - EPHA2 Segregates with Microphthalmia and Congenital Cataracts in Two Unrelated Families

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Figure 3

Reduced eye size in epha2a and epha2b morphant zebrafish. (a) Uninjected wild-type control embryos at 3 dpf; (b) morpholino knockdown of epha2a, (c) epha2b, and (d) epha2a/epha2b resulted in reduced eye size. Variable phenotype was seen with epha2b morphants, some with milder (i) or more severe eye (ii) features including lens opacification and coloboma. (e) Eye diameter measurement at 3 dpf showed a significant decrease in epha2a, epha2b and epha2a/epha2b morphants compared to uninjected wild-type controls. Unpaired t-tests were used to compare data. * p < 0.05, **** p < 0.0001. Scale bar = 500 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-epha2a WT + MO1-epha2b WT + MO1-epha2a + MO1-epha2b
Knockdown Reagents:	MO1-epha2a MO1-epha2b
Observed In:	eye lens optic fissure whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.