FIGURE

FIGURE 4

ID

ZDB-FIG-220921-41

Publication

He et al., 2022 - Tibetan medicine salidroside improves host anti-mycobacterial response by boosting inflammatory cytokine production in zebrafish

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FIGURE 4

Combined treatment of SAL and INH significantly improve the survival of zebrafish during mycobacterial infection. (A) Survival rates of M. marinum-infected zebrafish embryos treated with various concentrations of INH and SAL. n = 20 per group. (B) Representative images for the distribution of M. marinum (Wasabi) in different groups of zebrafish embryos at 72 hpi. Scale bar: 200 μm. (C) Statistics of integrated green fluorescence intensity in (B). One-way ANOVA was applied for the comparison. (D) Expression of two potent pro-inflammatory cytokines at 12 hpi. n = 30 per sample. A and D: data are representative of three independent biological replicates. B and C data are representative of two independent repeats.

Expression Data

Genes:	il1b tnfa
Fish:	AB
Conditions:	bacterial treatment by injection: Mycobacterium marinum bacterial treatment by injection: Mycobacterium marinum, chemical treatment by environment: Salidroside
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	bacterial treatment by injection: Mycobacterium marinum bacterial treatment by injection: Mycobacterium marinum, chemical treatment by environment: isoniazide bacterial treatment by injection: Mycobacterium marinum, chemical treatment by environment: isoniazide bacterial treatment by injection: Mycobacterium marinum, chemical treatment by environment: Salidroside
Observed In:	defense response to bacterium whole organism
Stage Range:	Long-pec to Days 14-20

Phenotype Detail

Acknowledgments

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