FIGURE

Figure 7

ID

ZDB-FIG-240620-205

Publication

Wei et al., 2024 - Ace Deficiency Induces Intestinal Inflammation in Zebrafish

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Figure 7

The IBD model was successfully constructed using DSS. (A) A diagram of IBD model development. (B) Changes in DSS-treated and untreated wild-type larvae were examined by qRT-PCR for several pro-inflammatory factors: ilb, lect2l, cxcl8b, mmp9, and mpx. Data represent the mean ± SD. * p < 0.05, ** p < 0.01. Three independent biological replicates were performed. (C) Line chart of survival rates comparing ace^−/− mutants and wild-type larvae treated as the DSS dose (% (w/v)) increased from 0% to 1% (n = 50). The significance of differences is annotated above the nodes in the line chart. * p < 0.05, ** p < 0.01. (D) HE staining shows a more severely disorganized intestinal epithelium in ace^−/− mutants compared with the wild type at 6 dpf following DSS treatment.

Expression Data

Genes:	cxcl8b.1 il1b lect2.1 mmp9 mpx
Fish:	AB
Condition:	chemical treatment by environment: dextran sulfate sodium
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB ace^{ouc1004/ouc1004} (AB)
Condition:	chemical treatment by environment: dextran sulfate sodium
Observed In:	intestinal epithelium intestinal mucosa intestine intestine lumen whole organism
Stage:	Day 6

Phenotype Detail

Acknowledgments

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