FIGURE

Fig. 6

ID

ZDB-FIG-250107-57

Publication

Wu et al., 2024 - New application of ombuoside in protecting auditory cells from cisplatin-induced ototoxicity via the apoptosis pathway

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Fig. 6

Ombuoside protects zebrafish hair cells from cisplatin-induced damage. A–D. Tg(brn3c:GFP) Zebrafish larvae at 5 dpf were pre-exposed in ombuoside for 2 h, and then co-treated with 800 μmol/L cisplatin for 8 h. Confocal microscopy was used to detect the green fluorescent protein (GFP) expression of hair cells, N ≥ 8. E. Assessment of the number of hair cells per neuromast in Fig. .6A–D, N ≥ 8.F. Relative expression of apoptosis-associated mRNA in zebrafish treated with cisplatin alone or co-treated with ombuoside, N = 3. Data are presented as mean ± SEM. ∗P ≤ 0.05, ∗∗P ≤ 0.01, ∗∗∗P ≤ 0.001, and ∗∗∗∗P ≤ 0.0001. Scale bar: 10 μm.

Expression Data

Genes:	baxb bcl2a pmaip1 tp53
Fish:	AB WT
Conditions:	chemical treatment by environment: cisplatin chemical treatment by environment: cisplatin chemical treatment by environment: antioxidant
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB WT s356tTg (AB)
Conditions:	chemical treatment by environment: cisplatin chemical treatment by environment: cisplatin chemical treatment by environment: antioxidant
Observed In:	neuromast hair cell whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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