FIGURE

Fig. 2

ID

ZDB-FIG-250417-84

Publication

Ezer et al., 2025 - Transcriptome analysis of atad3-null zebrafish embryos elucidates possible disease mechanisms

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Fig. 2

Mitochondrial characterization and ATP content of atad3-null larvae. Mutants in blue, siblings in grey. (A) mtDNA content comparison between pools of mutant embryos and their healthy siblings (5 dpf); 3 biological replicates of pools (3–8 mutants each, 6–11 siblings each). (B) ATP content in the heads of 6 dpf embryos, relative to average sib ATP content measured on the same day; four biological replicates, two from each day. 3 heads in each sample. (C) Enzymatic activity of COX and complex II + III normalized to SDH activity relative to the average enzymatic activity of siblings. Measured from 3 biological replicates, 7–9 heads of 5 dpf larvae in each sample. Error bars indicate standard error of means. Asterisks represent levels of significance (*p < 0.05, **p < 0.01, ***p < 0.001)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atad3^{zf4266/zf4266} (AB/TL)
Observed In:	head ATP head cytochrome-c oxidase activity head mitochondrial respiratory chain complex II assembly head mitochondrial respiratory chain complex III assembly whole organism mitochondrial chromosome
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

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