FIGURE
Figure 7
- ID
- ZDB-FIG-251107-76
- Publication
- Li et al., 2025 - PCSK9 Loss-of-Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects
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Figure 7
The schematic diagram of our findings. PCSK9 acts as a molecular chaperone that promotes LIN28A degradation via the lysosomal pathway. Furthermore, LIN28A, an RNA‐binding protein, ultimately affects the expression of JMY by regulating the transcription factor HES5. Aberrant elevation of JMY influences the organization of the cellular microfilament network, thereby impacting cell morphology. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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