FIGURE

FIGURE 2

ID

ZDB-FIG-251113-112

Publication

Ding et al., 2025 - An mTOR-Tfeb-Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging

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FIGURE 2

Cardiomyocyte‐specific overexpression of tfeb decelerated cardiomyocyte senescence. (A, B) Representative images of cryosectioned heart tissues co‐immunostained using either anti‐p16 antibody co‐stained with anti‐Mef2 antibody (A) or anti‐γH2A antibody co‐stained with anti‐α‐actinin antibody (B) in the bag3^e2/e2; Tg(cmlc2:tfeb) double‐mutant/transgenic fish compared to single‐mutant/transgenic fish and WT control fish at 6 months. Scale bars: 20 μm. Arrows point to overlapping signals. (C, D) Quantification of the numbers of p16/Mef2 and γH2A.X/α‐actinin antibodies co‐immunostained cells shown in A and B. n = 5, One‐way ANOVA. (E–H) Quantitative RT‐PCR analysis of cellular senescence marker p21 and senescence‐associated secretory phenotype (SASP) markers in bag3^e2/e2; Tg(cmlc2:tfeb) double mutant/transgenic fish compared to single‐mutant/transgenic fish and WT control fish. n = 3 biological replicates, one‐way ANOVA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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