FIGURE

Fig. 4

ID

ZDB-FIG-260526-4

Publication

Bastos et al., 2026 - Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration in zebrafish

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Fig. 4

Wholemount in situ hybridization demonstrates ctsz expression in cells in the injured tailfin. (A-Biii) In situ hybridization of ctsz in unchallenged larvae at 3 dpf (A) highlighting cells overlying the heart cavity (Bi), the intestinal bulb (Bii) and mid-intestine (Biii). (C) Tailfin injury schematic view demonstrating the analysed area in the in situ hybridization of ctsz experiments. (D) Representative images of in situ hybridization of ctsz in unstimulated wild-type (WT) (top row) and injured WT (bottom row) larvae at different time points. Numbers at bottom right indicate the number of analysed animals. Yellow arrowheads indicate staining at recruited individual leukocytes. Yellow dashed line outlines the intestinal bulb. Scale bars: 1 mm (A); 500 µm (D); 330 µm (Bi).

Expression Data

Gene:	ctsz
Fish:	WT
Condition:	transection: caudal fin
Anatomical Terms:	heart intestinal bulb mid intestine regenerating fin
Stage Range:	Protruding-mouth to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	transection: caudal fin
Observed In:	regenerating fin
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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