FIGURE

Fig. 5

ID

ZDB-FIG-260526-5

Publication

Bastos et al., 2026 - Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration in zebrafish

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Fig. 5

ctsz in situ hybridization shows reduced expression in ctsz crispant larvae. (A) Tailfin injury schematic view demonstrating the analysed area in the in situ hybridization of ctsz experiments. (B) Representative images of in situ hybridization of tyrosinase (top row) and ctsz (middle and bottom rows) at 24 h post-injury (hpi) (left column) and 48hpi (right column). There were two phenotypes in the ctsz knockdown larvae: weak ctsz expression (middle row) and a relatively higher expression of ctsz at the wound site (lower row) at both 24 and 48 hpi. Numbers at bottom right indicate the numbers with that phenotype and total number of analysed larvae. Scale bar: 500 μm.

Expression Data

Gene:	ctsz
Fish:	WT + CRISPR1-ctsz + CRISPR2-ctsz WT + CRISPR1-tyr
Condition:	transection: caudal fin
Knockdown Reagents:	CRISPR1-ctsz CRISPR1-tyr CRISPR2-ctsz
Anatomical Term:	regenerating fin
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + CRISPR1-ctsz + CRISPR2-ctsz WT + CRISPR1-tyr
Condition:	transection: caudal fin
Knockdown Reagents:	CRISPR1-ctsz CRISPR1-tyr CRISPR2-ctsz
Observed In:	regenerating fin
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.