ZFIN is now using GRCz12tu for Genomic Data
Gene
prkci
- ID
- ZDB-GENE-011105-1
- Name
- protein kinase C, iota
- Symbol
- prkci Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable phospholipid binding activity and protein serine/threonine kinase activity. Acts upstream of with a negative effect on apical protein localization. Acts upstream of or within several processes, including digestive tract development; morphogenesis of an epithelium; and nervous system development. Located in plasma membrane and zonula adherens. Is expressed in several structures, including blastoderm; common cardinal vein; epidermal cell; eye; and posterior lateral line primordium. Orthologous to human PRKCI (protein kinase C iota).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu720 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000270 | PB1 domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Domain | IPR034661 | Atypical protein kinase C iota type, catalytic domain |
| Domain | IPR034877 | Protein kinase C, PB1 domain |
| Domain | IPR053793 | PB1-like domain |
| Family | IPR012233 | Protein kinase C |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Atypical protein kinase C iota type, catalytic domain | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | PB1 domain | PB1-like domain | Protein kinase, ATP binding site | Protein kinase C | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase C, PB1 domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DI53 | InterPro | 588 | ||||||||||||||
| UniProtKB:Q90XF2 | InterPro | 588 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-prkcz | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
104 |
Plasmids
No data available
- Genome Browsers