ZFIN is now using GRCz12tu for Genomic Data
Gene
ptk2ab
- ID
- ZDB-GENE-020114-1
- Name
- protein tyrosine kinase 2ab
- Symbol
- ptk2ab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in regulation of convergent extension involved in gastrulation. Acts upstream of or within with a positive effect on midbrain-hindbrain boundary morphogenesis. Acts upstream of or within lens fiber cell morphogenesis and regulation of protein localization. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR005189 | Focal adhesion kinase, targeting (FAT) domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041390 | Focal adhesion kinase, N-terminal |
| Domain | IPR041784 | FAK1/PYK2, FERM domain C-lobe |
| Domain | IPR049385 | FAK1-like, FERM domain C-lobe |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036137 | Focal adhesion kinase, targeting (FAT) domain superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptk2ab-201
(1)
|
Ensembl | 3,874 nt | ||
| mRNA |
ptk2ab-202
(1)
|
Ensembl | 3,299 nt | ||
| mRNA |
ptk2ab-203
(1)
|
Ensembl | 6,468 nt | ||
| mRNA |
ptk2ab-211
(1)
|
Ensembl | 5,753 nt | ||
| mRNA |
ptk2ab-212
(1)
|
Ensembl | 5,865 nt | ||
| mRNA |
ptk2ab-213
(1)
|
Ensembl | 6,036 nt | ||
| mRNA |
ptk2ab-214
(1)
|
Ensembl | 6,486 nt | ||
| mRNA |
ptk2ab-215
(1)
|
Ensembl | 5,664 nt | ||
| mRNA |
ptk2ab-216
(1)
|
Ensembl | 6,015 nt | ||
| ncRNA |
ptk2ab-002
(1)
|
Ensembl | 845 nt | ||
| ncRNA |
ptk2ab-003
(1)
|
Ensembl | 885 nt | ||
| ncRNA |
ptk2ab-005
(1)
|
Ensembl | 768 nt | ||
| ncRNA |
ptk2ab-006
(1)
|
Ensembl | 645 nt | ||
| ncRNA |
ptk2ab-008
(1)
|
Ensembl | 537 nt | ||
| ncRNA |
ptk2ab-009
(1)
|
Ensembl | 808 nt | ||
| ncRNA |
ptk2ab-011
(1)
|
Ensembl | 722 nt |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ptk2 | polyclonal | IgG | Rabbit |
|
Life Technologies (Invitrogen)
|
11 | |
| Ab1-ptk2.1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
5 |
Plasmids
No data available
- Genome Browsers