ZFIN is now using GRCz12tu for Genomic Data
Gene
ptk2aa
- ID
- ZDB-GENE-031114-5
- Name
- protein tyrosine kinase 2aa
- Symbol
- ptk2aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in cell differentiation and positive regulation of cell population proliferation. Predicted to act upstream of or within protein phosphorylation and signal complex assembly. Predicted to be located in cytoskeleton; focal adhesion; and plasma membrane. Is expressed in head; midbrain; midbrain hindbrain boundary; and paraxial mesoderm. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR005189 | Focal adhesion kinase, targeting (FAT) domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041390 | Focal adhesion kinase, N-terminal |
| Domain | IPR041784 | FAK1/PYK2, FERM domain C-lobe |
| Domain | IPR049385 | FAK1-like, FERM domain C-lobe |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036137 | Focal adhesion kinase, targeting (FAT) domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | FAK1-like, FERM domain C-lobe | FAK1/PYK2, FERM domain C-lobe | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM domain | FERM superfamily, second domain | Focal adhesion kinase, N-terminal | Focal adhesion kinase, targeting (FAT) domain | Focal adhesion kinase, targeting (FAT) domain superfamily | PH-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2V4 | InterPro | 1045 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptk2aa-201
(1)
|
Ensembl | 2,931 nt | ||
| mRNA |
ptk2aa-202
(1)
|
Ensembl | 295 nt | ||
| mRNA |
ptk2aa-203
(1)
|
Ensembl | 1,150 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ptk2 | polyclonal | IgG | Rabbit |
|
Life Technologies (Invitrogen)
|
11 | |
| Ab3-ptk2 | monoclonal | IgG1 , k | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers