ZFIN is now using GRCz12tu for Genomic Data
Gene
jun
- ID
- ZDB-GENE-030131-7859
- Name
- Jun proto-oncogene, AP-1 transcription factor subunit
- Symbol
- jun Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Contributes to DNA-binding transcription factor activity and beta-catenin binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including canonical Wnt signaling pathway; response to cadmium ion; and response to methylmercury. Part of transcription regulator complex. Is expressed in several structures, including digestive system; hematopoietic system; mesoderm; musculature system; and sensory system. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77457 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gan et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004827 | Basic-leucine zipper domain |
| Domain | IPR005643 | Jun-like transcription factor |
| Family | IPR002112 | Transcription factor Jun |
| Family | IPR050946 | AP-1 Transcription Factor bZIP |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
| Homologous_superfamily | IPR046347 | Basic-leucine zipper domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AP-1 Transcription Factor bZIP | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily | Jun-like transcription factor | Transcription factor Jun | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NZT5 | InterPro | 308 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers