ZFIN is now using GRCz12tu for Genomic Data

Gene

smad9

ID

ZDB-GENE-031014-1

Name

SMAD family member 9

Symbol

smad9 Nomenclature History

Previous Names

madh9
smad8
zgc:103407 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within dorsal/ventral pattern formation; myeloid cell development; and negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including cardiovascular system; gut; nervous system; optic vesicle; and periderm. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human SMAD9 (SMAD family member 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103407 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smad9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary pulmonary hypertension	Alliance	Pulmonary hypertension, primary, 2	615342

Associated With smad9 Via Experimental Models

Human Disease	Fish	Conditions	Citations
arteriovenous malformations of the brain	zf531Tg + MO1-smad9	standard conditions	Walcott et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR013019	MAD homology, MH1
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR017855	SMAD-like domain superfamily
Homologous_superfamily	IPR036578	SMAD MH1 domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	MAD homology 1, Dwarfin-type	MAD homology, MH1	SMAD/FHA domain superfamily	SMAD-like domain superfamily	SMAD MH1 domain superfamily
UniProtKB:F1QXZ9	InterPro	466

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	smad9-001 (1) Ensembl	Ensembl	2,359 nt	Select Tool ZFIN BLAST
mRNA	smad9-201 (1) Ensembl	Ensembl	5,365 nt	Select Tool ZFIN BLAST
mRNA	smad9-205 (1) Ensembl	Ensembl	2,691 nt	Select Tool ZFIN BLAST
mRNA	smad9-206 (1) Ensembl	Ensembl	2,291 nt	Select Tool ZFIN BLAST
ncRNA	smad9-002 (1) Ensembl	Ensembl	917 nt	Select Tool ZFIN BLAST
ncRNA	smad9-003 (1) Ensembl	Ensembl	526 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-smad	polyclonal	smad1 smad5 smad9	IgG	Rabbit	IHC WB	Cell Signaling Technology, Inc.	79

Plasmids

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations