ZFIN is now using GRCz12tu for Genomic Data
Gene
smad1
- ID
- ZDB-GENE-991119-8
- Name
- SMAD family member 1
- Symbol
- smad1 Nomenclature History
- Previous Names
-
- madh1
- fb39h09
- sb:eu786
- SMA- and MAD-related protein 1
- wu:fb39h09 (1)
- wu:fb97e04
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables transcription cis-regulatory region binding activity. Involved in BMP signaling pathway; embryonic pattern specification; and regulation of DNA-templated transcription. Acts upstream of or within dorsal/ventral pattern formation; myeloid cell development; and negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including artery; immature eye; mesoderm; nervous system; and postcranial axial skeleton. Orthologous to human SMAD1 (SMAD family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92101 (19 images)
- eu786 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001132 | SMAD domain, Dwarfin-type |
| Domain | IPR003619 | MAD homology 1, Dwarfin-type |
| Domain | IPR013019 | MAD homology, MH1 |
| Family | IPR013790 | Dwarfin |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
| Homologous_superfamily | IPR036578 | SMAD MH1 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dwarfin | MAD homology 1, Dwarfin-type | MAD homology, MH1 | SMAD domain, Dwarfin-type | SMAD/FHA domain superfamily | SMAD-like domain superfamily | SMAD MH1 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9I8V2 | InterPro | 472 | |||||||
| UniProtKB:Q5PQZ2 | InterPro | 472 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available
- Genome Browsers