dlx2a

ID

ZDB-GENE-980526-212

Name

distal-less homeobox 2a

Symbol

dlx2a Nomenclature History

Previous Names

dlx-2
dlx2
zgc:110518

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neural crest cell development; pharyngeal system development; and skeletal system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; cranial cartilage; neural crest; pectoral fin bud; and pharyngeal arch. Orthologous to human DLX2 (distal-less homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

444 figures from 302 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu96 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlx2a Human Ortholog

No data available

Associated With dlx2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Domain	IPR022135	Distal-less-like homeobox protein, N-terminal domain
Family	IPR050460	Distal-less homeobox transcription factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily