ZFIN is now using GRCz12tu for Genomic Data
Gene
dla
- ID
- ZDB-GENE-980526-29
- Name
- deltaA
- Symbol
- dla Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Notch binding activity. Acts upstream of or within several processes, including embryonic organ development; nervous system development; and regulation of Notch signaling pathway. Located in cell cortex and plasma membrane. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural plate; and neural tube. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 126 figures from 78 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb335 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures | 618709 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Family | IPR051022 | Notch Signaling and Cell Fate Determination |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain | Notch Signaling and Cell Fate Determination |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R7K3 | InterPro | 772 | |||||||||
| UniProtKB:Q6DI48 | InterPro | 772 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available
- Genome Browsers