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Xiao et al., 2022 - A novel uveitis model induced by lipopolysaccharide in zebrafish

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Figure 5

Prednisone immersion treatment inhibited EIU inflammation in zebrafish. (A) Live cells were separated out from the retina cell suspensions of Tg(Mpx:GFP) line. Left, Flow cytometry was used to analyze the GFP-positive neutrophils. Right, quantification of percentages of GFP-positive cells in different conditions (n = 4 per group; mean ± SD; ***P < 0.001; ****P < 0.0001; ns, not significant; one-way ANOVA). (B) Left, flat mounts of retina around the optic disc in Tg(Mpx:GFP) line. Scale bar, 20μm. Right, quantification of the relative GFP-positive area in retinal flat mounts in different conditions (mean ± SD; n = 3 retinas per group; ****P < 0.0001; one-way ANOVA). (C) Transcript levels of proinflammatory genes of retina in zebrafish treated with 0.1% DMSO (vehicle-treated group) or 50μm prednisone (mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; unpaired t-test).

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol