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Fig. 7 Schematic representation of the direct interaction between filamin-C, Drp1, and F-actin during mitochondrial fission, as well as the consequences of filamin-C deficiency. In the absence of filamin-C, Drp1 remains unactivated, leading to impaired mitochondrial fission. This disruption in fission subsequently results in mitophagy and mitochondrial dysfunction.
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Full text @ Hum. Mol. Genet.