ZFIN Image: Tevar et al., 2025, Fig. 10

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Figure Caption

Fig. 10 Top 50 DEGs in adamtsl4 KO zebrafish identified by RNA-seq analysis and confirmation by RT-qPCR of the differential expression of selected genes. A-B. Downregulated genes and upregulated genes, respectively, in 6 dpf lethal adamtsl4 KO larvae vs. wild type larvae. C-D. Downregulated genes and upregulated genes, respectively, in 6 dpf wild type-like adamtsl4 KO larvae vs. wild type larvae. E-F. Downregulated genes and upregulated genes, respectively, in eyes of 5-month adamtsl4 KO zebrafish vs. wild type zebrafish. G-H. Confirmation by qRT-PCR of differential gene expression of selected upregulated and downregulated genes, respectively, in lethal adamtsl4 KO larvae vs. wild type larvae. I-J. Confirmation by qRT-PCR of differential gene expression of selected upregulated and downregulated genes, respectively, in eyes of 5-monts adamtsl4 KO zebrafish vs. wild type zebrafish. Aliquots of RNA preparations used for transcriptomic analyses were used as templates in qRT-PCR that was carried out in triplicate.

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Reprinted from Experimental Eye Research, , Tevar, A., Aroca-Aguilar, J.D., Atiénzar-Aroca, R., Ramírez, A.I., Fernández-Albarral, J.A., Escribano, J., Zebrafish adamtsl4 knockout recapitulates key features of human ADAMTSL4-related diseases: a gene involved in extracellular matrix organization, cell junctions and development, 110572110572, Copyright (2025) with permission from Elsevier. Full text @ Exp. Eye. Res.