FIGURE

Figure 3.

ID

ZDB-FIG-231031-19

Publication

Liu et al., 2023 - Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model

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Figure 3.

CNCC migration was inhibited in teratogen-treated sox10:EGFP embryos. (A–F′) Migratory CNCCs were visualized in sox10:EGFP embryos at 10 ss. The yellow arrowheads show the position of the midbrain-hindbrain boundary(MBH). The white arrowheads represent the anterior border of the migratory CNCCs. All teratogens inhibited CNCC migration. (G) Quantification of the distance between the MHB (yellow arrowheads) and the anterior border of the migratory CNCCs via the frontonasal pathway (white arrowheads). Control: n = 21, VPA: n = 22, WA: n = 19, SA: n = 22, CAF: n = 22, MTX: n = 23. *p < .05, **p < .01, ***p < .001 (1-way ANOVA followed by Dunnett’s multiple comparison test). e: eye. Scale bar: 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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