FIGURE

Figure 8.

ID

ZDB-FIG-231031-24

Publication

Liu et al., 2023 - Identification of an adverse outcome pathway (AOP) for chemical-induced craniofacial anomalies using the transgenic zebrafish model

Other Figures

All Figure Page

Back to All Figure Page

Figure 8.

Conserved craniofacial morphogenesis during the pharyngeal stage and the AOP of craniofacial anomalies identified in the present study. (A) Schematic comparison of craniofacial morphogenesis between mammals (mouse) and zebrafish. Zebrafish and mammals share conserved craniofacial morphogenesis. At the pharyngeal stage, the frontonasal prominence (FNP), maxillary prominence (MxP) and mandibular prominence (MdP) are formed in both species. FNP and each region in the PA1 differentiate into craniofacial elements. (B) Identified AOP of chemical-induced craniofacial anomalies. (C) AOP-based teratogenicity assay utilizing the sox10 transgenic lines. PA1 morphology at 24 hpf and craniofacial morphology at 96 hpf are practical endpoints of teratogenicity evaluation and prediction.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Toxicol. Sci.