FIGURE

Fig. 2

ID

ZDB-FIG-250521-36

Publication

Þorsteinsson et al., 2025 - Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records

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Fig. 2

Acute effects of amlodipine and methylphenidate on impulsivity in adult zebrafish.

A The test tank and schematic overview of the 5-CSRTT. B Proportion of premature responses in age matched wild-type and adgrl3.1^−/− adult zebrafish. C Effects of amlodipine (10 µM) and methylphenidate (10 µM) on impulsive responses in adgrl3.1^−/− adult zebrafish. Data are depicted as mean ± SEM., N = 48, Linear Mixed Model; *P = 0.05; **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	adgrl3.1^{zf3892/zf3892}
Conditions:	chemical treatment by environment: amlodipine chemical treatment by environment: methylphenidate
Observed In:	associative learning regulation of behavior
Stage:	Adult

Phenotype Detail

Acknowledgments

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