FIGURE

Fig. 7

ID

ZDB-FIG-250902-80

Publication

Abramova et al., 2025 - Disruption of grin2A, an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafish

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Fig. 7

Effects of grin2Aa or grin2Ab deletion on grin mRNA expression in zebrafish larvae. Relative expression levels of grin1 (A), grin2A (B), and grin2B (C) mRNA in heads of zebrafish larvae (6 dpf) for grin2A+/+, grin2Aa−/−, grin2Ab−/−, and grin2A−/− fish were analyzed by RT-qPCR. One-way ANOVA was used to assess the differences in the relative expression of each gene, followed by multiple comparisons versus the corresponding gene in the grin2A+/+ larvae (Dunnett's method), with significance as indicated. grin1a, p = 0.028; grin1b, p = 0.010; grin2Aa, p < 0.001; grin2Ab, p < 0.001; grin2Ba, p = 0.030; grin2Bb, p = 0.011; n = 6 for each genotype, grin2A+/+, grin2Aa−/−, grin2Ab−/−, and grin2A−/−, for each analysis. For effects of grin2Aa or grin2Ab deletion on grin mRNA expression in the adult zebrafish, see Extended Data Figure 7-1.

Expression Data

Genes:	grin1a grin1b grin2aa grin2ab grin2ba grin2bb
Fish:	AB grin2aa^{sa14573/sa14573} (AB) grin2ab^czf1/czf1 (AB) grin2aa^{sa14573/sa14573}; grin2ab^czf1/czf1 (AB)
Anatomical Term:	head
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grin2aa^{sa14573/sa14573} (AB) grin2ab^czf1/czf1 (AB) grin2aa^{sa14573/sa14573}; grin2ab^czf1/czf1 (AB)
Observed In:	head
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurosci.