FIGURE

FIGURE 1

ID

ZDB-FIG-260319-78

Publication

Pistocchi et al., 2026 - Neurotrophic Modulation Restores Motor and Developmental Defects in Zebrafish Models of ints11 Deficiency

Other Figures

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FIGURE 1

ints11 deficient embryos displayed developmental delay and altered motor response. (A–C) Representative images of 4 dpf controls (ctrl) injected with (A) either standard morpholino (std‐MO) or Cas9/tracrRNA and larvae injected with (B) ints11‐sMO and (C) ints11‐sgRNA. Scale bar indicates 300 μm. (D) Touch‐evoked escape response assay performed at 2.5 dpf in controls (n = 40), ints11‐sMO (n = 38) and ints11‐sgRNA (n = 42) embryos. Proportion of embryos with normal TR: Ctrl 39/40; ints11‐sMO: 13/38; ints11‐sgRNA: 12/42. Proportion of embryos with altered TR: Ctrl 1/40; ints11‐sMO: 25/38; ints11‐sgRNA: 30/42. In the histograms the percentage of embryos is expressed as mean ± SEM. Chi‐squared test with Holm–Bonferroni. Refer to Table S3 for raw statistical data. ***p < 0.001. ns not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + CRISPR1-ints11 + CRISPR2-ints11 AB + MO2-ints11
Knockdown Reagents:	CRISPR1-ints11 CRISPR2-ints11 MO2-ints11
Observed In:	thigmotaxis whole organism whole organism blood circulation
Stage Range:	Pec-fin to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurochem.