FIGURE

Figure S6.

ID

ZDB-FIG-260509-21

Publication

Gillotay et al., 2026 - The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models

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Figure S6.

Transcriptomic profiling of Nrf2 KO–derived thyroid organoids.
(A) Heatmap of normalized bulk RNA-seq expression of thyroid genes and Nrf2 pathway effectors among Nrf2 WT and KO cells. Rows represent markers and columns conditions. Color values in the heatmap represent mean expression levels. (B, C) Gene ontology classification of the down-regulated (B) and up-regulated (C) genes in Nrf2 KO–derived thyrocytes (red: KEEG pathway; orange: biological process; green: molecular function; violet: MSigDB Hallmark, 2020). (D) Heatmap representing the expression profile of Nrf2 target genes exhibiting an antioxidant responsive element within their promoter and/or regulatory regions. (E) STRING analysis predicts a strong association network involving the up-regulated transcription factors observed in Nrf2 KO condition, with a main core comprising Fos and Jun genes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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