FIGURE

FIGURE 6

ID

ZDB-FIG-260520-79

Publication

Ononuju et al., 2026 - Employing zebrafish to understand genetic drivers of epilepsy-related comorbid behaviors

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FIGURE 6

Clemizole and stiripentol alleviates light and tap startle abnormalities in Dravet zebrafish model. Six dpf scn1lab mutant larvae (identified by black pigmentation) were transferred to a 96-well microplate and treated with 25 µM valproic acid (Val), 25 µM stiripentol (Stir) or 25 µM clemizole (Clem) for 30 min prior to initiation of light or startle stimuli. Heat maps summarize the effects of drugs on mean velocity movements in the presence of the (A) three light flashes and (B) three taps. Line graphs illustrate the effects of the drugs before, during and after (C) light and (D) tap stimuli. Statistical significance highlighted in heat maps are excluded for visual clarity in (C,D). Plots are represented as mean ± SEM. Post hoc Dunnett’s multiple comparison test *p < 0.05, **p < 0.01 and ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scn1lab^s552/s552
Conditions:	chemical treatment by environment: clemizole, light intensity chemical treatment by environment: clemizole, vibration chemical treatment by environment: Stiripentol, light intensity chemical treatment by environment: Stiripentol, vibration chemical treatment by environment: valproic acid, vibration
Observed In:	startle response
Stage:	Day 6

Phenotype Detail

Acknowledgments

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