IMAGE

Figure 6

ID

ZDB-IMAGE-260623-17

Genes

Publication

Capecki et al., 2026 - Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix

All Figures

Figures for Capecki et al., 2026

Image

Figure Caption

Figure 6

Differential expression of leading-edge extracellular matrix (ECM) genes in 4 dpf ddr2a CRISPR-F0 zebrafish larvae (zfl) heads compared with scrambled controls (scr-ctrl). (A) volcano plot showing log₂ fold change versus –log₁₀ adjusted p-value for ECM-related leading-edge genes identified by absolute gene-set enrichment analysis (GSEA). Each dot represents one gene. The dashed vertical line marks no change in expression, and the horizontal dashed line indicates the significance cutoff (p_adj < 0.05). In total, 62 of 71 significantly dysregulated genes were down-regulated in ddr2a F0-KOs, 9 were up-regulated. (B) Heatmap of log₂ fold changes for the top 30 leading-edge genes identified by absolute GSEA in the comparison of ddr2a F0-KO versus scrambled control (P = 0.049). Gene expression changes were derived from DESeq2 differential expression analysis. Colors indicate the direction and magnitude of the expression.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.