FIGURE

Fig. 4

ID

ZDB-FIG-250115-4

Publication

Shipman et al., 2024 - Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants

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Fig. 4

Impaired vision in vps4aT248I mutants. A, 5 dpf vps4aT248I mutants (N = 10) have a severely reduced optomotor response compared with wild-type siblings (N = 12); Mann–Whitney test; p < 0.0001 (exact). B, Decreased b-wave amplitude in ERGs of 5–6 dpf vps4aT248I mutants (N = 34) in comparison with wild-type siblings (N = 23) occurs at brighter light intensities (log −4 to log 0); Kruskal–Wallis test (log 0, p < 0.0001; log −1, p < 0.0001; log −2, p < 0.0001; log −3, p = 0.0014; log −4, p = 0.1989). C, HCR RNA-FISH of gap43, jun, and opn1sw1 in the eye of vps4aT248I mutants compared with wild-type siblings. Pr, photoreceptors; Rg, retinal ganglion cells, lens.

Expression Data

Genes:	gap43 jun opn1sw1
Fish:	vps4a^st201/st201
Anatomical Terms:	lens photoreceptor cell retinal ganglion cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vps4a^st201/st201
Condition:	lighting conditions
Observed In:	lens Muller cell phototransduction ON-bipolar cell phototransduction optomotor response photoreceptor cell retinal ganglion cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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