FIGURE

Fig. 3

ID

ZDB-FIG-250318-57

Publication

Zhou et al., 2025 - Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish

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Fig. 3

Retinal degeneration in dync1h1−/− zebrafish at 5 dpf. (A) Representative H&E-stained images of WT and dync1h1−/− retina. (B–E) TEM images of WT and dync1h1−/− retina. (B) Overview of the outer retina. (C) Mitochondria indicated by white arrows and zoom-in pictures shown in the red rectangle. (D) ER (white arrow). (E) Golgi (white arrow). (F) Immunofluorescence-stained cryosections showing PRC IS/OS using anti-Nok and PNA; nuclei are stained by DAPI. (G) Immunofluorescence-stained cryosections showing OLM integrity using anti-ZO1; nuclei stained by DAPI. (H) TUNEL assay images with DAPI-stained nuclei. −/−, dync1h1 homozygote. Scale bar = 50 µm (A, F–H), 5 µm (B), 2 µm in (C), 500 nm (D, E). DAPI, 4′,6-diamidino-2-phenylin-dole; dpf, days post fertilization; ER, endoplasmic reticulum; H&E, hematoxylin and eosin; IS/OS, inner segment/outer segment; Nok, nagie oko; ONL, outer nuclear layer; PNA, peanut agglutinin; PRC, photoreceptor cell; WT, wild type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.