FIGURE

FIGURE 2

ID

ZDB-FIG-250407-44

Publication

Tatzl et al., 2025 - Deficiency of the Synaptic Adhesion Protein Leucine-Rich Repeat Transmembrane Protein 4 Like 1 Affects Anxiety and Aggression in Zebrafish

Other Figures

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FIGURE 2

lrrtm4l1^−/− zebrafish display heightened anxiety. (a) Schematic representation of the lrrtm4l1 gene. The black line within exon 2 indicates the position of the nonsense mutation of the sa21708 zebrafish mutant line. Numbers represent bp positions. (b) Representative tracking heatmaps of lrrtm4l1^+/+ (WT) and lrrtm4l1^−/− (KO) zebrafish in the open field test. (c) KO zebrafish swim a shorter distance and (d) spend less time in the centre zone of the open field test. (e) KO animals show no difference in time spent immobile, but (f) display increased angular velocity. (g) Representative swimming trajectories of WT and KO zebrafish in the novel tank diving test. (h) KO zebrafish spend less time in the top zone and (i) enter the top zone of the test tank less frequently. n = 23‐28/group. Student's t test or Mann–Whitney U test. **p < 0.01;*p < 0.05 KO versus WT. Data are presented as mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrrtm4l1^{sa21708/sa21708}
Observed In:	behavioral fear response
Stage:	Adult

Phenotype Detail

Acknowledgments

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