FIGURE

FIGURE 4

ID

ZDB-FIG-250609-50

Publication

Mesika et al., 2025 - Impaired Proteostasis is Linked to Neurological Pathology in a Zebrafish NGLY1 Deficiency Model

Other Figures

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FIGURE 4

Amyloid aggregation in adult NGLY1‐deficient zebrafish brains. Representative histological images of ngly1^(+/+)(A, B, F, G) and ngly1^(−/−)(C, D, H, I) zebrafish brain and optic tectum (TeO) reacted with an antibody against amyloid fibrils (A–D) and Congo Red (F–I), demonstrating significant aggregation of amyloid fibrils (black arrows) at the intracellular space of the mutant fish brain. Magnifications: (F, H): X10, (A, C, G, H): X20, and (B, D): X40. Scale bar: 100 μm. (E, J) Quantification of amyloid fibers by Immunohistochemistry and Congo Red staining, respectively. ***T‐test, p < 0.001 (N = 10 per group).

Expression Data

Antibody:	Ab11-app
Fish:	AB ngly1^{zf3678/zf3678} (AB)
Anatomical Terms:	brain optic tectum
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ngly1^{zf3678/zf3678} (AB)
Observed In:	brain brain amyloid-beta complex optic tectum optic tectum amyloid-beta complex
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Inherit. Metab. Dis.