FIGURE

Fig. 7

ID

ZDB-FIG-250917-63

Publication

Tevar et al., 2025 - Zebrafish adamtsl4 knockout recapitulates key features of human ADAMTSL4-related diseases: a gene involved in extracellular matrix organization, cell junctions and development

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Fig. 7

Histological analysis of hematoxylin-eosin-stained tissue sections from adult adamtsl4 KO zebrafish (5 months). Transverse tissue sections were prepared as described in the Materials and Methods section. Representative photographs of wild type (+/+) and KO (−/−) zebrafish are shown. A-B. Tissue sections from the central part of the eyeball highlighting the presence of the optic nerve (ON). C-D. Anterior segment. E-F. Corneal structure. G. Quantitative analysis of corneal thickness. ∗∗: p < 0.01. Rectangles indicate areas magnified in subsequent panels. Arrows: separation of lens fibers; Asterisks: abnormal annular ligament.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	adamtsl4^ucl6/ucl6 (AB)
Observed In:	annular ligament adaxial-abaxial axis cornea cornea ventral side corneal epithelium corneal epithelium superficial side lens fiber cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Experimental Eye Research, , Tevar, A., Aroca-Aguilar, J.D., Atiénzar-Aroca, R., Ramírez, A.I., Fernández-Albarral, J.A., Escribano, J., Zebrafish adamtsl4 knockout recapitulates key features of human ADAMTSL4-related diseases: a gene involved in extracellular matrix organization, cell junctions and development, 110572110572, Copyright (2025) with permission from Elsevier. Full text @ Exp. Eye. Res.