FIGURE

Fig. 6

ID

ZDB-FIG-251017-10

Publication

Xian et al., 2025 - ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish

Other Figures

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Fig. 6

Effects of Atp5fa1 reduction on mitochondrial structure and function in zebrafish larvae. A Ultrastructure of mitochondria in the neurons of zebrafish larvae of the control group (control-MO) and atp5fa1 gene knockdown group (atp5fa1-MO) under transmission electron microscopy (The red framed area is a local magnified view, and the arrow indicates the disordered cristae structure or vacuolization; scale bar: 2 μm in the main image, 500 nm in the magnified image). B Comparison of the activity of mitochondrial complex V in zebrafish between the control group and atp5fa1-MO group (Mean ± SD; ***P < 0.001, Student t-test)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ml3Tg + MO2-atp5f1a (AB)
Knockdown Reagent:	MO2-atp5f1a
Observed In:	mitochondrial proton-transporting ATP synthase complex assembly neuron mitochondrial crista neuron mitochondrial matrix
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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