FIGURE

Fig. 5

ID

ZDB-FIG-251017-9

Publication

Xian et al., 2025 - ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish

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Fig. 5

Effects of Atp5fa1 reduction on zebrafish motor function. A Representative images of peripheral neurons in transgenic (mnx1:mGFP) zebrafish at 72hpf. Scale bar, 200 μm. B Movement trajectories of 120hpf zebrafish larvae in the control group (control-MO), atp5fa1 knockdown group (atp5fa1-MO), atp5fa1-MO and ATP5F1A mRNA co-injection group (n = 8 embryos/group). The lines indicate movement trajectories. C Quantification analysis of total swimming distance. (Mean ± SD, n = 8 embryos/group; ****P < 0.0001, Student t-test). D Quantification analysis of velocity. (Mean ± SD, n = 8 embryos/group; ****P < 0.0001, Student t-test). E Curves showing changes in swimming distance over time for zebrafish larvae in the control group, atp5fa1-MO group and atp5fa1-MO group + ATP5F1A mRNA during the light-dark alternation experiment. Swimming distance represents cumulative distance recorded every 5 min.

Expression Data

Gene:	GFP
Fish:	ml3Tg (AB) ml3Tg + MO2-atp5f1a (AB)
Knockdown Reagent:	MO2-atp5f1a
Anatomical Term:	primary motor neuron axon
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ml3Tg + MO2-atp5f1a (AB)
Knockdown Reagent:	MO2-atp5f1a
Observed In:	primary motor neuron axon swimming behavior
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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