FIGURE

FIGURE 7

ID

ZDB-FIG-251216-11

Publication

Chen et al., 2025 - Ddx3xa mutations drive cardiac defects in a zebrafish model via dysregulation of wnt/β-catenin signaling

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FIGURE 7

Validation and pathway analysis of cardiac development genes in ddx3xa^−/− zebrafish. (A) qRT-PCR validation of genes related to cardiac contraction, vascular smooth muscle contraction, calcium signaling, and actin cytoskeleton regulation in ddx3xa^−/− mutants versus wild-type (WT) at 72 hpf (n = 3; *P < 0.05, **P < 0.01, ***P < 0.001). (B) Pathway-gene interaction network for enriched cardiac development pathways generated using Cytoscape. (C) Heatmap of RNA-Seq expression profiles for enriched genes across key cardiac development pathways.

Expression Data

Genes:	adcy7 chrm2b cxcl12b itgae.1 itpka ntrk1 ntsr1 p2rx3a pla2g4aa pla2g4f.1 plcd1a ptger1b rac1l
Fish:	AB ddx3xa^hn102/hn102 (AB)
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ddx3xa^hn102/hn102 (AB)
Observed In:	whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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