FIGURE

FIGURE 10

ID

ZDB-FIG-250322-10

Publication

Le et al., 2025 - A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

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FIGURE 10

c1q levels measured by RT-qPCR in control and crim1^−/− larvae that are homozygous for a 2 base pair deletion, c.339_340delCT p.Leu112Leufs*3, at 72 h post fertilization (hpf). RT-qPCR showing expression of c1qa, c1qb, c1qc, cd74a, and cd74b in crim1^−/− larvae compared to controls. RT-qPCR was performed on dissected eyes for all experiments from control (white columns; expression normalized to 1.0) and crim1^−/− larvae (black columns) at 72 hpf. The results show significantly increased expression of c1qb (P = 0.018) and significantly reduced expression of c1qc (P = 0.003) and cd74b (P = 0.032) in crim1^−/− larvae compared to controls. c1qa (P = 0.154) and cd74a (P = 0.391) expression was not significantly different.

Expression Data

Genes:	c1qa c1qb c1qc cd74a cd74b
Fish:	EKW crim1^s4007/s4007 (EKW)
Anatomical Term:	eye
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	crim1^s4007/s4007 (EKW)
Observed In:	eye
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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